capsules (protonic pump inhibitor) antiacidic, antiulcerous

1 capsule contains 20 mg of omeprazol.
Omeprazol is a protonic pump inhibitor that reduces the gastric acidity by blocking the enzymatic system hydrogen-kalium adenosine triphosphate (“protonic pump”) of the gastric parietal cells. In combination with antibiotics, this drug is irreplaceable in eradication of Helicobacter pylori. Omeprazol is especially effective in cases resistant to other antisecretory drugs. In therapeutic doses, omeprazol maintains the pH of the stomach around 3, in duration of 16 to 18 hours.
Duodenal ulcer, ventricular ulcer, “resistant ulcer”, oesophageal reflux, Zolinger-Elison syndrome, eradication of Helicobacter pylori in combination with other antimicrobic substances.
There are no known contraindications to omeprazol.
Dosage and administration
Omeprazol should be administered prior meal, preferably prior having a breakfast. Capsules have to be swollen with a little water.
Duodenal ulcer:
Preferably, 1 capsule of 20 mg, once a day, in 2 weeks. In cases of an ulcer resistant to other drugs, dose might increase to 40 mg/day.
Gastric ulcer:
Preferably, 1 capsule of 20 mg, once a day, in 8 weeks. In severe cases, dose might increase to 40 mg, once a day.
Gastroesophageal reflux
Preferably, 1 – 2 capsules (20 mg – 40 mg/day), 4 to 8 weeks.
Resistant ulcer
Preferably, 2 capsules of omeprazol (40 mg), once a day, in 4 weeks. If improvement is not achieved, therapy continues for 4 more weeks.
Zolinger-Elison syndrome
Initial dose is 60 mg, once a day (3 capsules of omeprazol). Dose should adjust to individual needs, treatment continues as long as clinically necessary. Therapy might administer for more than 5 consecutive years. If the daily dose of omeprazol is over 80 mg, 2 divided doses are to be administered. Highest daily dose is not allowed to be over 120 mg/day.
Eradication of Helicobacter pylori
In treatment of infections with H.pylori, besides use of Omeprazol, it is necessary to administer some other antibiotic too, respectively triple therapy:
- 2 times a day 20 mg of Omeprazol,
- 2 times a day 1000 mg of amoxicillin,
- 2 times a day 500 mg metronidazol.
This combination is administered for 7 days, whilst Omeprazol continues for 14 more days.
Side effects
Omeprazol is well tolerated by patients. Rare side effects that can occur are as follows: diarrhoea, constipation, abdominal pain, headache, dizziness, rash, urticaria and pruritus. In rare cases, are observed hematologic disorders such follows: leukopenia, neutropenia, thrombocytopenia, interstitial nephritis. Changes in hepatic enzymes, gynecomastia, impotence, and stomatitis.
Store at room temperature from 15ºC - 25ºC, in a dry place and protected from the light.
Keep out of the reach of children.
This is a prescription drug only!
Expiry date
See the package.
Package with 14 capsules of 20 mg.

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